Martinš Jansons, PhD

To help customers advance scientific discovery, Thermo Fisher Scientific unveiled the Thermo Scientific™ OptiSpray™ technology at the ASMS 2025 conference in Baltimore. High-quality data is essential for modern mass spectrometry applications such as proteomics, single-cell analysis, metabolomics, and biomarker discovery – especially as researchers increasingly work with smaller sample amounts and demand high sensitivity and precision.

Achieving optimal performance in low-flow LC-MS can be challenging due to emitter positioning and electrospray stability issues. The Thermo Scientific™ OptiSpray™ ion source addresses these challenges by integrating separation column, liquid junction, and replaceable emitter into a single cartridge unit. Combined with a motorized XYZ stage and software-driven optimization routines, OptiSpray automates emitter alignment based on real signal, minimizing user variability and improving reproducibility.

This design streamlines setup, improves stability, and enhances overall robustness. Whether applied to high-throughput or low-input analyses, OptiSpray enables reliable and sensitive detection of low-abundance features without compromising chromatographic performance, while greatly improving precision.

Compatible with Thermo Fisher Scientific mass spectrometers – Orbitrap™ Astral™, Orbitrap Tribrid™, Orbitrap Excedion™ Pro, Stellar™, and TSQ Plus™ systems – OptiSpray brings confidence and ease to workflows, empowering researchers of all experience levels to generate high-quality LC-MS data across platforms and expedite critical discoveries.